Oncotarget Findings on Respiratory Mechanisms in Infants with Severe Bronchiolitis

One of the leading causes of childhood mortality worldwide is respiratory infections. A common lower respiratory infection called bronchiolitis has continued to be a major problem among pediatricians, especially considering it is a self-limited infection. However, some infants develop respiratory failure with increase in work-of-breathing (WOB) and hypoxemia and require mechanical ventilation to aid other supportive measures. Modern ventilators can be used as a supportive machine as well as a bedside monitoring tool that can express lung functions through measures of flow and pressure. According to equation of motion, deep analysis of respiratory mechanics significantly discriminates different elements of WOB when substantial pressure is applied to the respiratory system.

Interpreting the data after conducting advanced analysis can help medical experts tailor mechanical ventilation parameters that match physiological processes of the disease.Bronchiolitis is considered as an airway obstructive disease through physical observation. Since bronchodilator therapy has not been extremely effective, a better understanding of respiratory mechanics in severe bronchiolitis is crucial to comprehend the disease in order to improve current ventilation strategies. This will ultimately improve on the usual outcomes such as mechanical ventilation duration, hospital length of stay and support requirements. Having all these facts, Oncotarget – a renowned multidisciplinary journal, conducted a study to examine respiratory mechanics on infants with acute bronchiolitis.

A total of 54 infants were screened with bronchiolitis. The study used measurements obtained from two conventional contemporary ventilators that measured pulmonary mechanics of the infants. Results obtained from the study concluded that the respiratory system elastic component determines the work imposed on mechanical ventilation.Oncotarget aims at providing scientific results more rapidly and widely to the medical field researchers and the general public by working closely with high profile scientific indexes and archives. In order to accelerate that process, Oncotarget has assured its readers that they will be publishing two issues each week. This will also facilitate the journal achieve its primary goal of becoming the first journal to have its entire issue published by PubMed few days after online publication.

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